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To drain a large blister, sterilize a needle and poke a small hole on one edge of the raised area. Leave the needle under the skin, let the water drain, then insert the end of an antibiotic salve tube in the hole. Squeeze in some salve so the blister is filled with it rather than water. The loose skin will protect the new skin that's healing underneath and the antibiotic salve will protect against infection.
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